The measurement of SARS-CoV-2-specific antibodies was performed using the Elecsys Anti-SARS-CoV-2 immunoassay (Roche Diagnostics, Basel, Switzerland). This semiquantitative electrochemiluminescence immunoassay measures SARS-CoV-2 nucleocapsid-specific IgG. The assay was performed by the South African National Health Laboratory Service and interpreted according to the manufacturer's instructions (Roche: version 1.0 2020-05). Results are reported as numeric values in the form of a cut-off index (COI) (signal sample/cut-off), where a COI <1.0 corresponds to nonreactive plasma and a COI ⩾1.0 corresponds to reactive plasma. At 14 days post-SARS-CoV-2 PCR confirmation, the sensitivity and specificity of the Elecsys Anti-SARS-CoV-2 immunoassay has been reported as 99.5% (95% CI 97.0–100.0%) and 99.80% (95% CI 99.69–99.88%), respectively [10 (link)–12 (link)].
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SARS-CoV-2 Antibody Measurement via Elecsys Assay
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Antibodies
Assay
Diagnostics
Immunoassay
National health service
Nucleocapsid
Plasma
Sars cov 2
South african
Corresponding Organization :
Other organizations : University of Cape Town, Wellcome Centre for Infectious Diseases Research in Africa, International Centre for Genetic Engineering and Biotechnology, Imperial College London, Scripps Research Institute, The Francis Crick Institute
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Variable analysis
independent variables
- Independent variables not explicitly mentioned.
- The measurement of SARS-CoV-2-specific antibodies using the Elecsys Anti-SARS-CoV-2 immunoassay.
- Control variables not explicitly mentioned.
- A cut-off index (COI) ≥1.0 corresponds to reactive plasma.
- A cut-off index (COI) <1.0 corresponds to nonreactive plasma.
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