MRI-based Assessment of Stroke Lesion Volume

MRI was conducted using a 1.5-T scanner (Achieva, Philips Medical Systems, Best, The Netherlands) for all patients. T2-weighted images (turbo spin-echo, reconstructed voxel size = 0.45 × 0.45 × 5.00 mm³) and three-dimensional T1-weighted images (turbo field-echo, reconstructed voxel size = 0.94 × 0.94 × 1.00 mm³) were obtained to cover the whole brain. To compute stroke LV, lesions of each patient were manually drawn on the T2-weighted images, and they were spatially normalized to the Montreal Neurological Institute stereotaxic space, using the Clinical Toolbox^{37 (link)} in SPM8³⁸ (Wellcome Trust Centre for Neuroimaging, London, UK). Details of the MRI acquisition conditions are fully described in our previous report^{10 (link)}.

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Kawano T., Hattori N., Uno Y., Hatakenaka M., Yagura H., Fujimoto H., Nagasako M., Mochizuki H., Kitajo K, & Miyai I. (2021). Association between aphasia severity and brain network alterations after stroke assessed using the electroencephalographic phase synchrony index. Scientific Reports, 11, 12469.

Publication 2021

1.5-T scanner

Brain Echo Patient Stroke

Corresponding Organization :

Other organizations : Morinomiya Hospital, RIKEN Center for Brain Science, Osaka University

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Variable analysis

independent variables

1.5-T scanner (Achieva, Philips Medical Systems, Best, The Netherlands)

dependent variables

Stroke lesion volume (LV)

control variables

Reconstructed voxel size for T2-weighted images (0.45 × 0.45 × 5.00 mm^3)
Reconstructed voxel size for three-dimensional T1-weighted images (0.94 × 0.94 × 1.00 mm^3)
Spatial normalization to the Montreal Neurological Institute stereotaxic space using the Clinical Toolbox in SPM8

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