Organ-Based Dosimetry Protocol for Radiation Dose Estimation

The absorbed doses for both cohorts were calculated in a similar way, as previously described [19 (link)]. In short, volumetric organ-based dosimetry was performed according to the scheme defined by the Committee on Medical Internal Radiation Dose [20 (link)] using Hermes HybridViever/Dosimetry (Hermes Medical Solutions, Stockholm, Sweden). All SPECT/CT images were co-registered per patient, followed by drawing volumes of interest of the kidneys. Kidney absorbed radiation dose was determined in Olinda 2.1 (Hermes Medical Solutions, Stockholm, Sweden) using gender-specific human kidney weights based on the ICRP Publication 89 [21 ], corresponding S-values and a mono-exponential fit.