COVID-19 Diagnostic Biomarker Assessment

The diagnosis of COVID-19 was confirmed in all patients with viral reverse transcriptase PCR using the Xpert^® Xpress SARS-CoV-2 (singleplex) cartridge and device (GeneXpert, Cepheid GmbH, 47807 Krefeld, Germany), as previously described [33 (link)]. Interleukin-6 (IL-6), ferritin, NTproBNP, cTnT, and C-reactive protein (CRP) were measured with commercial immunoassays on a COBAS 8000 analyzer (Roche Diagnostics, Rotkreuz, Switzerland). We measured vitamin K by a newly developed LC-MS/MS method [32 (link)]. The overall precision of all analytes (combination of intra and inter-assay CVs) ranged between 4.8% and 17.7%. D-Dimer, prothrombin time, activated partial thromboplastin time (aPTT), antithrombin (AT), protein C, free protein S, and factor XIII were analyzed on a Siemens Atellica COAG-360 analyzer (Siemens Healthineers, Marburg, Germany).

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Mangge H., Prueller F., Dawczynski C., Curcic P., Sloup Z., Holter M., Herrmann M, & Meinitzer A. (2022). Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients. Antioxidants, 11(7), 1235.

Publication 2022

GeneXpert COBAS 8000 analyzer Atellica COAG-360 analyzer

Activated partial thromboplastin time Antithrombin Assay C reactive protein Coag Covid 19 D dimer Device Diagnostics Factor xiii Ferritin Immunoassays Interleukin 6 Ms ms Ntprobnp Patients Protein c Protein s Prothrombin time Reverse transcriptase pcr Sars cov 2 Vitamin k

Corresponding Organization : Medical University of Graz

Other organizations : Friedrich Schiller University Jena

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Interleukin-6 (IL-6)
Ferritin
NTproBNP
C-reactive protein (CRP)
Vitamin K
D-Dimer
Prothrombin time
Activated partial thromboplastin time (aPTT)
Antithrombin (AT)
Protein C
Free protein S
Factor XIII

control variables

Not explicitly mentioned

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

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