Cannabinoid Receptor Modulation in TNBS-Induced Colitis

Drugs were injected intraperitoneally. JWH133 (20 mg/kg body weight once or twice daily), AM1241 (10 or 20 mg/kg body weight twice daily), and AM630 (10 mg/kg body weight once daily) were dissolved in a vehicle solution (2% DMSO and 1% Tween 80 in saline) and injected either 30 minutes before the induction of colitis and then once or twice daily for 3 days following the induction of colitis (n = 6-8 each group). Vehicle (4 mL/ kg body weight) alone was injected in TNBS treated control animals (n = 6–8). The doses of JWH133, AM1241, and AM630 were chosen based on previously published studies or empirically determined in preliminary studies.^{10 (link)}