Five compounds known to inhibit PI3K activity, including LY294002 (Sigma-Aldrich)48 (link), 49 (link), quercetin (Abcam)50 (link), wortmannin (Cell Signaling Technology)51 (link), GNE493 (SYNkinase)34 (link), and GDC-0941 (Abcam)38 (link) were used for initial in vitro screening in a colony formation assay. GDC-0941 was selected for tumor suppression assay in an OX model with oral administration.
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