Example 1

Weekly periocular CF injections of DEX-Ac in both eyes in ANGPTL7 WT mice significantly elevated IOP in (see, FIG. 1). IOP measurements of DEX-Ac-treated (n=18) versus vehicle-treated (n=6) mice show IOP elevation from week 1 to 6; **p<0.01, ***p<0.001, ****p<0.0001. In contrast, weekly periocular CF injections of DEX-Ac in both eyes in ANGPTL7 KO mice did not elevate IOP (see, FIG. 1). IOP measurements of DEX-Ac-treated (n=20) versus vehicle-treated (n=12) ANGPTL7 KO mice showed no effect in IOP elevation from week 1 to week 6.

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