Dexamethasone-Induced IOP Elevation in Mice

Example 1

Weekly periocular CF injections of DEX-Ac in both eyes in ANGPTL7 WT mice significantly elevated IOP in (see, FIG. 1). IOP measurements of DEX-Ac-treated (n=18) versus vehicle-treated (n=6) mice show IOP elevation from week 1 to 6; **p<0.01, ***p<0.001, ****p<0.0001. In contrast, weekly periocular CF injections of DEX-Ac in both eyes in ANGPTL7 KO mice did not elevate IOP (see, FIG. 1). IOP measurements of DEX-Ac-treated (n=20) versus vehicle-treated (n=12) ANGPTL7 KO mice showed no effect in IOP elevation from week 1 to week 6.

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US11865134B2. Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (ANGPTL7) inhibitors (2024-01-09). Regeneron Pharmaceuticals, Inc. [US]. Inventors: Gaurang Patel [US], Ying Hu [US], Kavita Praveen [US], Giovanni Coppola [US], Goncalo Abecasis [US], Aris Baras [US], Carmelo Romano [US].

Patent 2024

Eyes Inhibit Mice Ocular hypertension Periocular injections

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Variable analysis

independent variables

Weekly periocular CF injections of DEX-Ac in both eyes

dependent variables

IOP (intraocular pressure) measurements

control variables

ANGPTL7 genotype (WT and KO mice)

positive controls

Weekly periocular CF injections of DEX-Ac in both eyes in ANGPTL7 WT mice

negative controls

Weekly periocular CF injections of DEX-Ac in both eyes in ANGPTL7 KO mice

Annotations

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