COVID-19 Vaccination Antibody Response in Breast Milk

In this observational longitudinal case series we used samples from an existing prospective longitudinal study COVID MILK – POWER MILK (28 (link)). All participants were subjected to longitudinal analysis of specific antibodies against the SARS-CoV-2 spike-protein by ELISA and general SIgA1 Fab clonal profiling in human milk after vaccination against COVID-19 with BNT162b2/Comirnaty developed by Pfizer-BioNTech, mRNA-1273/Spikevax developed by Moderna or AZD1222/Vaxzevria developed by Oxford/AstraZeneca. Ethical approval was acquired from an Independent Ethics Committee (2020.425/NL74752.029.20). The study was conducted in accordance with the principles of the declaration of Helsinki and the ICH GCP Guidelines, and the Regulation on Medical Research involving Human subjects.

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de Graaf S.C., Bondt A., van Rijswijck D.M., Juncker H.G., Mulleners S.J., Damen M.J., Hoek M., van Keulen B.J., van Goudoever J.B., Heck A.J, & Dingess K.A. (2024). A case series exploring the human milk polyclonal IgA1 response to repeated SARS-CoV-2 vaccinations by LC–MS based fab profiling. Frontiers in Nutrition, 10, 1305086.

Publication 2023

BNT162b2/Comirnaty mRNA-1273/Spikevax AZD1222/Vaxzevria

Corresponding Organization : Emma Kinderziekenhuis

Other organizations : Netherlands Institute for Neuroscience

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Variable analysis

independent variables

Type of COVID-19 vaccine administered (BNT162b2/Comirnaty, mRNA-1273/Spikevax, or AZD1222/Vaxzevria)

dependent variables

Specific antibodies against the SARS-CoV-2 spike-protein as measured by ELISA
General SIgA1 Fab clonal profiling in human milk

control variables

Participants were subjected to longitudinal analysis after vaccination against COVID-19

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

Annotations

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