Flutemetamol (18F) PET Imaging for Alzheimer's Detection

The PET images were acquired using a Biograph 40 TrueV HD PET/CT scanner (Siemens Healthineers AG, Erlangen, Germany) in the Department of Nuclear Medicine and PET Centre, Na Homolce Hospital. The participants received a single intravenous dose of flutemetamol (18F; Vizamyl, GE Healthcare, Chicago, IL). Non-contrast low-dose CT brain images were acquired for attenuation correction prior to the PET scans. A PET list-mode acquisition was performed in two phases: early (perfusion) and late (β-amyloid). The early-phase images were acquired at the time of flutemetamol (18F) administration for 8 min and rebinned into dynamic datasets of 2 × 4 min for motion checking. The late-phase images were acquired 90 min after flutemetamol (18F) administration for a total of 10 min (2 × 5 min). Flutemetamol (18F) PET images were visually read (as positive or negative) by a certified nuclear medicine specialist using the GM-EDGE method [60 (link)].

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Matuskova V., Veverova K., Jester D.J., Matoska V., Ismail Z., Sheardova K., Horakova H., Cerman J., Laczó J., Andel R., Hort J, & Vyhnalek M. (2024). Mild behavioral impairment in early Alzheimer’s disease and its association with APOE and BDNF risk genetic polymorphisms. Alzheimer's Research & Therapy, 16, 21.

Publication 2024

Biograph 40 TrueV HD Vizamyl

Corresponding Organization :

Other organizations : Charles University, VA Palo Alto Health Care System, Na Homolce Hospital, University of Calgary, St. Anne's University Hospital Brno, University Hospital Brno

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Variable analysis

independent variables

Flutemetamol (18F) administration

dependent variables

PET image acquisition
Visual reading of flutemetamol (18F) PET images as positive or negative

control variables

Non-contrast low-dose CT brain images for attenuation correction
PET list-mode acquisition in two phases: early (perfusion) and late (β-amyloid)

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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