Nimodipine and BayK8644 in vitro experiments

Nimodipine and BayK8644 were provided (batch: BXR4H3P, research grade) by Bayer AG (Leverkusen, Germany) on the basis of a material transfer agreement. Both substances were dissolved in DMSO (Thermo Fisher Scientific, Waltham, MA, USA) to obtain a 10 mM stock solution. We used a dose of 1 µM or 10 µM for in vitro experiments following recommendations of previously published studies [85 (link),86 (link),87 (link),88 (link),89 (link),90 (link)] and our own experience [20 (link)].

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Enders M., Weier A., Chunder R., An Y., Bremm F., Feigenspan A., Buettner C., Ekici A.B., Mingardo E., Odermatt B, & Kuerten S. (2023). Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells. International Journal of Molecular Sciences, 24(4), 3716.

Publication 2023

Nimodipine DMSO

Bayk8644 Dmso Nimodipine

Corresponding Organization : Friedrich-Alexander-Universität Erlangen-Nürnberg

Other organizations : Universitätsklinikum Erlangen

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Variable analysis

independent variables

Nimodipine concentration (1 µM or 10 µM)
BayK8644 concentration (1 µM or 10 µM)

dependent variables

Not explicitly mentioned

control variables

Solvent (DMSO) used to dissolve both substances
Previously published studies used as a basis for dose selection

controls

Positive controls: Not mentioned
Negative controls: Not mentioned

Annotations

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