Optimized Macular Vasculature Analysis

After all OCT-A scans were manually checked for artefacts, shadows and correct segmentation, macula data was exported from the clinical database and then imported into the prototype SP-X1902 software (Heidelberg Engineering, Heidelberg, Germany). The Anatomic Positioning System function (APS, part of Glaucoma Module Premium Edition [GMPE], Heidelberg Engineering, Germany) allows each scan to be aligned to the patient´s individual Fovea to Bruch’s Membrane Opening (FoBMOC) axis for better intra- and interindividual scan comparability. Integration of APS information was also implemented into the Erlangen Angio-Tool (EA-Tool) version 2.0, coded in Matlab (The MathWorks, Inc., R2017b). In addition to the APS information, the macular en face OCT-A images of SVP, ICP and DCP were imported into the EA-Tool and analyzed separately for each scan. Overall and sectorial macula VD (12 sectors s1-s12 á 30°) were analyzed for SVP, ICP and DCP, respectively. The analyzed region of the scan size was 6.10 mm².

Free full text: Click here

Müller M., Schottenhamml J., Hosari S., Hohberger B, & Mardin C.Y. (2023). APSified OCT-angiography analysis: Macula vessel density in healthy eyes during office hours. PLOS ONE, 18(3), e0282827.

Publication 2023

SP-X1902 software Glaucoma Module Premium Edition [GMPE], Matlab

Axis Bruch membrane Face Glaucoma Macula Patient Scan

Corresponding Organization : Friedrich-Alexander-Universität Erlangen-Nürnberg

Top 5 similar protocols

Variable analysis

independent variables

Alignment of OCT-A scans to patient's individual Fovea to Bruch's Membrane Opening (FoBMOC) axis using the Anatomic Positioning System (APS) function

dependent variables

Vessel density (VD) in the superficial vascular plexus (SVP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP) of the macula, analyzed overall and in 12 sectors (s1-s12) of 30° each

control variables

Manually checked OCT-A scans for artifacts, shadows, and correct segmentation before data export and analysis

controls

No positive or negative controls were explicitly mentioned in the provided information.

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!