Comprehensive Perinatal Health Evaluation

Self-reported maternal characteristics (e.g. demographics, medical, and obstetric history), and dietary and psychosocial (i.e. depression, resilience, traumatic and threatening experiences, anxiety, and perceived stress) information, are collected at the earliest prenatal visit. Anthropometry, self-reported exposure (e.g. alcohol, tobacco, marijuana, methamphetamines), and fetal physiology [e.g. heart rate (HR), heart rate variability (HRV), movement, HR-movement coupling] are collected at each prenatal visit. Biometry and Doppler ultrasound velocimetry of uterine and fetal vessels are performed for embedded study participants. Postnatal newborn and/or 1 month visits include autonomic, cardiorespiratory, cortical activity, and auditory assessments, self-reported exposure, infant care practices, infant anthropometrics, facial dysmorphology photographs, and the Amiel-Tison Neurologic Assessment at term.^{21 (link)} At the 1 year visit, the Mullen Scales of Early Learning²² is administered to assess cognitive ability and motor development (embedded study), and infant anthropometrics and facial dysmorphology photographs are collected. Maternal (pregnancy through delivery) and infant (newborn to 1 year) charts are abstracted to obtain information regarding growth, physical exam/fetal structure, laboratory testing, medications and interventions, clinical events, co-morbidities, and diagnoses. Serious adverse events, unanticipated problems, and concomitant services are collected at each participant visit, contact, or event, and are reported according to regulatory guidelines.