Diffusion Imaging of the Human Connectome

The HCP data was collected at Washington University, St. Louis, using a customized Siemens Magnetom Connectome 3 Tesla scanner with a 100 mT/m maximum gradient strength and a 32-channel head coil. Details on the scanner, image acquisition, and reconstruction are provided elsewhere (Ugurbil et al., 2013 (link)) and found online at (https://www.humanconnectome.org/study/hcp-young-adult/document/1200-subjects-data-release). Diffusion data was collected using a single-shot, single refocusing spin-echo, echo-planar imaging sequence with 1.25 mm isotropic spatial resolution (TE/TR = 89.5/5520 ms, FOV = 210 × 180 mm). Three gradient tables of 90 diffusion-weighted directions and 6 b = 0 images each, were collected with right-to-left and left-to-right phase encoding polarities for each of the three diffusion weightings (b = 1000, 2000, and 3000 s/mm²). The diffusion data were then processed using the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) pipeline for structural and diffusion tensor imaging, including skeletonized voxel-wise FA values (Jahanshad et al., 2013 (link)).

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Gao S., Donohue B., Hatch K.S., Chen S., Ma T., Ma Y., Kvarta M.D., Bruce H., Adhikari B.M., Jahanshad N., Thompson P.M., Blangero J., Hong L.E., Medland S.E., Ganjgahi H., Nichols T.E, & Kochunov P. (2021). Comparing empirical kinship derived heritability for imaging genetics traits in the UK biobank and human connectome project. NeuroImage, 245, 118700.

Publication 2021

Magnetom Connectome 3 Tesla scanner

Connectome Diffusion Echo Head Mt 100 Reconstruction Weightings Young adult

Corresponding Organization : University of Maryland, Baltimore

Other organizations : University of Maryland, College Park, University of Southern California, The University of Texas Rio Grande Valley, QIMR Berghofer Medical Research Institute, University of Oxford

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Variable analysis

independent variables

Diffusion weighting (b = 1000, 2000, and 3000 s/mm^2)

dependent variables

Skeletonized voxel-wise fractional anisotropy (FA) values

control variables

Scanner: Siemens Magnetom Connectome 3 Tesla scanner
Gradient strength: 100 mT/m maximum
Head coil: 32-channel
Spatial resolution: 1.25 mm isotropic
Echo time (TE) and repetition time (TR): 89.5/5520 ms
Field of view (FOV): 210 × 180 mm
Phase encoding polarities: right-to-left and left-to-right

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