PSMA-PET/CT and SPECT/CT Dosimetry

[⁶⁸Ga]Ga-PSMA-PET/CT imaging was performed on a Biograph mCT system (Siemens Healthineers, Erlangen, Germany) 1 week prior to each administration of [¹⁷⁷Lu]Lu-PSMA to evaluate PSMA-positive tumor lesions, following local clinical acquisition protocols [30 (link)]. Standardized uptake values (SUV) were determined for salivary gland (SUV_mean, spherical volumes of interest (VOIs) of 20 mm in diameter) and lesions (SUV_max). For dosimetry, all patients received SPECT/CT imaging at 1, 24, 48, 72, and 168 h after each therapy on either a Symbia T16 or Symbia Intevo Bold system (Siemens Healthineers, Erlangen, Germany). Both systems were cross-calibrated for ¹⁷⁷Lu with the in-house dose calibrator, which undergoes regular quality control according to national guidelines [31 ]. Three-bed position SPECT/CT scans were acquired including the pelvis, abdomen, and head/neck region. The acquisition and reconstruction protocol was followed as described by Peters et al. [32 (link)] and was in accordance with MIRD pamphlet no. 26 [33 (link)]. These protocols take into account scatter, attenuation, and dead-time corrections.

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Peters S.M., Privé B.M., de Bakker M., de Lange F., Jentzen W., Eek A., Muselaers C.H., Mehra N., Witjes J.A., Gotthardt M., Nagarajah J, & Konijnenberg M.W. (2021). Intra-therapeutic dosimetry of [177Lu]Lu-PSMA-617 in low-volume hormone-sensitive metastatic prostate cancer patients and correlation with treatment outcome. European Journal of Nuclear Medicine and Molecular Imaging, 49(2), 460-469.

Publication 2021

Biograph mCT system Symbia T16 Symbia Intevo Bold

177lu Abdomen Clinical protocols Dosimetry Ga psma Head Neck Patients Pelvis Pet ct Reconstruction Salivary gland Spect ct scans Therapy Tumor

Corresponding Organization : Radboud University Nijmegen

Other organizations : University of Duisburg-Essen, Erasmus MC

Top 5 similar protocols

Variable analysis

independent variables

[⁶⁸Ga]Ga-PSMA-PET/CT imaging
[¹⁷⁷Lu]Lu-PSMA therapy

dependent variables

PSMA-positive tumor lesions
Standardized uptake values (SUV) for salivary gland (SUV_mean) and lesions (SUV_max)

control variables

Biograph mCT system (Siemens Healthineers, Erlangen, Germany) for [⁶⁸Ga]Ga-PSMA-PET/CT imaging
Symbia T16 or Symbia Intevo Bold system (Siemens Healthineers, Erlangen, Germany) for SPECT/CT imaging
In-house dose calibrator for cross-calibration of ¹⁷⁷Lu, which undergoes regular quality control according to national guidelines
Acquisition and reconstruction protocol as described by Peters et al. [32] and in accordance with MIRD pamphlet no. 26 [33]
Scatter, attenuation, and dead-time corrections

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