Nationwide Multicenter Study of Non-valvular Atrial Fibrillation

The Cohort of Antithrombotic Use and Optimal INR Level in Patients with Non-valvular Atrial Fibrillation in Thailand (COOL-AF Thailand) registry was a prospective nationwide multicenter study of patients with non-valvular AF aged more than 18 years. The exclusion criteria were as follows: (i) rheumatic mitral valve disease; (ii) prosthetic mechanical valve; (iii) inability to have a follow-up visit; (iv) life expectancy less than 3 years; (v) AF from transient reversible cause; (vi) ischemic stroke of less than 3 months; (vii) hematologic disease that increased the risk of bleeding such as myeloproliferative disease; and (viii) refusal to participate.
The study was approved by the Central Research Ethics Committee (CREC) with the Certificate of Approval number COA-CREC 003/2014. Written informed consent was obtained prior to participation.