Genetic Diversity Analysis of Hepatitis C

Subjects in this study were participants in one of 6 studies: (i) AIDS Link to Intravenous experience (ALIVE)^{21 (link)} (N = 281); (ii) Multicenter Hemophilia Cohort Study (MHCS)^{22 (link)} (N = 305); (iii) Hemophilia Growth and Development Study (HGDS)^{23 (link)} (N = 106); (iv) Correlates of Resolved Versus Low Level Viremic Hepatitis C Infection in Blood Donors study (REVELL) (N = 85); (v) an HCV clinic cohort in Portland, Oregon (N = 51); (vi) a cohort of injection drug users from the UK (N = 180) (see Methods for details). Fifty one worldwide populations (N = 2371) from the ALlele FREquency Database (ALFRED)^{24 (link)}, were also genotyped in this study. Details of sampling and ethnographic information for these populations can be found at http://alfred.med.yale.edu/. All populations were in Hardy-Weinberg equilibrium with the exception of one, the Finnish sample (n = 33, p = 0.05). Genotyping was performed using the ABI TaqMan allelic discrimination kit and the ABI7900HT Sequence Detection System (Applied Biosystems, Foster City, CA). SAS 9.1 (SAS Institute) was used for statistical analyses.

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Thomas D.L., Thio C.L., Martin M.P., Qi Y., Ge D., O’hUigin C., Kidd J., Kidd K., Khakoo S.I., Alexander G., Goedert J.J., Kirk G.D., Donfield S.M., Rosen H.R., Tobler L.H., Busch M.P., McHutchison J.G., Goldstein D.B, & Carrington M. (2009). Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature, 461(7265), 798-801.

Publication 2009

Aids Allelic Blood donors Discrimination Drug users Hemophilia Populations Viremic

Corresponding Organization : Science Applications International Corporation (United States)

Other organizations : Johns Hopkins University, Duke University, Yale University, Imperial College London, University of Cambridge, National Cancer Institute, Rho (United States), University of Colorado Health, University of Colorado Anschutz Medical Campus, Blood Systems Research Institute, Clinical Research Institute

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

None explicitly mentioned

control variables

Hardy-Weinberg equilibrium, with the exception of one population (the Finnish sample)
Genotyping was performed using the ABI TaqMan allelic discrimination kit and the ABI7900HT Sequence Detection System (Applied Biosystems, Foster City, CA)

controls

Negative control: Finnish sample (n = 33, p = 0.05) not in Hardy-Weinberg equilibrium

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