PEL was kindly provided by Daewon Pharm. Co., Ltd. (Seoul, Korea). Eudragit® RL PO and Eudragit® RS PO were obtained from Evonik Korea Ltd. (Seoul, Korea). 3-Aminopropyltriethoxysaline (ATPES, 99%), sodium taurodeoxycholate (NaTDC), and tolbutamide were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). Lecithin (ca. 99.2% soy bean phosphatidylcholine) was purchased from Avanti lipid (USA). Magnesium chloride hexahydrate (98%) and other inorganic salts were obtained from Junsei Chemical Co., Ltd. (Tokyo, Japan). Aminoclay was prepared by the method reported by Yang et al. (2013 (link)). Acetone was purchased from Daejung chemical & metals Co., Ltd. (Gyeonggi-Do, Korea). All other chemicals were of analytical grade and all solvents were of high performance liquid chromatography (HPLC) grade.
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