Two additional groups of 6 animals were submitted to CA but received saline (control) or the RAGE antagonist FPS‐ZM1 (1 mg/kg IV) after ROSC. Rabbits awaken 6 hours after ROSC for the evaluation of neurological outcome for 72 hours, as previously described for the glycyrrhizin study. At the end of the 72‐hour follow‐up, animals were euthanized and brain lesions were evaluated by fluorojade C staining.
Protocol detail
Evaluating RAGE Antagonist for Post-Cardiac Arrest
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Corresponding Organization :
Other organizations : Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, École Nationale Vétérinaire d'Alfort, Inserm, Institut de Recherche Vaccinale
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Variable analysis
independent variables
- Administration of saline (control) or the RAGE antagonist FPS‐ZM1 (1 mg/kg IV) after ROSC
- Neurological outcome evaluation for 72 hours after ROSC
- Brain lesions evaluated by fluorojade C staining at the end of the 72‐hour follow-up
- Rabbit model
- Time of neurological outcome evaluation (6 hours after ROSC for 72 hours)
- Positive control: Rabbits receiving the RAGE antagonist FPS‐ZM1 after ROSC
- Negative control: Rabbits receiving saline (control) after ROSC
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