Male Swiss mice (Janvier Laboratories, Saint Isle, France). Mice were fed ad libitum.
Female BALB/c mice aged 5 to 7 weeks were purchased from Janvier Laboratories, France. Mice were housed at 5 animals per cage with sterile bedding in HEPA–filtered racks (Tecniplast, France) in certified animal biosafety level 3 (ABSL-3) laboratories. Temperatures were maintained at 65-75°F (∼18-23 °C) with 40-60% humidity. Specific pathogen-free status was verified by testing sentinel mice housed within the same rack. Mice had ad libitum access to water and food pellets.
For combination studies, Female BALB/c mice 6-8 weeks old, purchased from Charles River (Wilmington, MA, USA) were used.
Other organizations :
Sanofi (France), Evotec (United States), Texas A&M University, University of Illinois at Chicago, Institut de génétique et de biologie moléculaire et cellulaire, TB Alliance, Johns Hopkins Medicine, Johns Hopkins University
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