Details of each of the samples (including sample size, ancestry, and whether included in the previous publication by the PGC) are given in Supplementary Cohort Descriptions. The core PGC dataset included 90 cohorts for which we had individual level genotype data fully processed under a uniform pipeline. This core dataset contains genotypes on 161,405 unrelated subjects; 67,390 schizophrenia/schizoaffective disorder cases and 94,015 controls, equivalent in power to 73,189 of each. A parent-proband trio is considered to comprise one case and one control. Approximately half (31,914 cases and 47,176 controls) of the samples were not included in the previous GWAS of the PGC1 . Around 80% of the probands (53,386 cases and 77,258 controls) were of European Ancestry, and the remainder (14,004 cases and 16757 controls) were of East Asian ancestry2 . We additionally included in the Primary GWAS summary statistics from 9 cohorts comprising African-American (AA; 6152 cases 3918 controls) and Latino (1234 cases, 3090 controls) participants; the combined sample is equivalent in power to 6,551 each of cases and controls. 1249 LD – independent (r2 > 0.1) Variants showing evidence for association (P< 1×10−5) were further meta-analysed with an additional dataset of 1,979 cases and 142,626 controls of European ancestry obtained from deCODE genetics, thus the final analysis represents 320,404 diploid genomes.