In a study described by Kuo et al.25 (link), gastric emptying time as assessed by a non-digestible solid (wireless motility capsule) and gastric emptying as measured by standard scintigraphy (GES) were found to exhibit comparable sensitivity and specificity for detection of gastroparesis. Healthy controls and patients with previously confirmed gastroparesis (diabetic and idiopathic) were enrolled at 7 academic medical centers and this study on gastric emptying is the source database for this analyses for regional, and whole gut transit times25 (link). The study was approved by the Institutional Review Board of each participating center and each subject gave informed consent before entering the study. The Clinical Trial is registered with: clinicaltrials.gov , registry number: NCT001282884
This investigation assessed gastric, small bowel, colonic and whole gut transit times. Eligibility was limited to subject data containing the four physiological landmarks necessary to assess regional transit (ingestion, gastric emptying, ileocecal arrival and body exit). The physiological landmarks used are discernable by changes in the pH or temperature profiles and are described later in this section.
This investigation assessed gastric, small bowel, colonic and whole gut transit times. Eligibility was limited to subject data containing the four physiological landmarks necessary to assess regional transit (ingestion, gastric emptying, ileocecal arrival and body exit). The physiological landmarks used are discernable by changes in the pH or temperature profiles and are described later in this section.
