VDRLoxP mice were originally developed by Dr. Geert Carmeliet (Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium). To obtain specific knockout of myeloid VDR (VDRΔLyz), we crossed VDRLoxP mice with lysozyme(M)-cre mice (The Jackson Laboratory, Bar Harbor, ME, USA) (9 (link)). The mice were provided with water ad libitum and maintained in SPF conditions in Biology Research Laboratory of University of Illinois Chicago with 12-hour light/12-hour dark cycle. All animal work was approved by the University of Illinois Chicago (UIC) Committee on Animal Resources (Animal Protocol Number ACC 18-179).
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Inducible Myeloid VDR Knockout Mice
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Corresponding Organization : Jesse Brown VA Medical Center
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Variable analysis
independent variables
- Genotype: Crossbreeding VDR^LoxP mice with lysozyme(M)-cre mice to obtain VDR^ΔLyz mice
- Not explicitly mentioned
- Water ad libitum
- Specific pathogen-free (SPF) conditions
- 12-hour light/12-hour dark cycle
- Positive control: VDR^LoxP mice
- Negative control: Not mentioned
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