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Systematic Review of Hormone Receptor Testing

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ASCO and CAP commissioned a systematic review of the literature on hormone receptor testing published since 1990. That review conducted by ASCO and CCO is being published separately (manuscript in preparation) and served as the primary source of the evidence for this guideline. Articles were selected for inclusion in the systematic review if they met the following prospective criteria. Studies comparing IHC in paraffin-embedded female breast cancer sections with another assay and comparative studies whose objectives were to improve or validate the quality of IHC studies that linked test performance to clinical outcome were specifically sought. Systematic reviews, consensus statements, and practice guidelines from 1990 onward were included if they addressed hormone receptor testing in female breast cancer using IHC in paraffin-embedded sections or gene expression signatures for ER and PgR. A cutoff date of 1990 was chosen because this was the time that IHC began to come into common use. Additional details of the literature search strategy are provided in the Systematic Review (manuscript in preparation).

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Hammond M.E., Hayes D.F., Dowsett M., Allred D.C., Hagerty K.L., Badve S., Fitzgibbons P.L., Francis G., Goldstein N.S., Hayes M., Hicks D.G., Lester S., Love R., Mangu P.B., McShane L., Miller K., Osborne C.K., Paik S., Perlmutter J., Rhodes A., Sasano H., Schwartz J.N., Sweep F.C., Taube S., Torlakovic E.E., Valenstein P., Viale G., Visscher D., Wheeler T., Williams R.B., Wittliff J.L, & Wolff A.C. (2010). American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer. Archives of pathology & laboratory medicine, 134(6), 907-922.

Publication 2010

Assay Breast cancer Embedded paraffin Female Hormone

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Protocol cited in 107 other protocols

Variable analysis

independent variables

Hormone receptor testing method (e.g., IHC in paraffin-embedded female breast cancer sections, gene expression signatures for ER and PgR)

dependent variables

Test performance (linked to clinical outcome)

control variables

Time period (1990 onwards when IHC began to come into common use)

controls

Positive controls: Not explicitly mentioned
Negative controls: Not explicitly mentioned

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