Immunohistochemistry was performed on pretreatment tissue specimens to assess PD-L1 expression using the Dako 22C3 antibody (Agilent, Santa Clara, CA, USA). The TPS was used to measure results, as previously described (21 (link)) with cut points of < 1%, ≥ 1% to 49%, and ≥ 50%. Insufficient tissue and unknown PD-L1 status were included in the < 1% cut point category.
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PD-L1 Expression Assessment Protocol
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Corresponding Organization : Moffitt Cancer Center
Other organizations : Cardiovascular Medical Group
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Variable analysis
independent variables
- PD-L1 expression
- TPS (Tumor Proportion Score)
- Pretreatment tissue specimens
- Dako 22C3 antibody (Agilent, Santa Clara, CA, USA)
- Insufficient tissue and unknown PD-L1 status were included in the < 1% cut point category.
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