Two different kinds of plots can be generated: overview plots and plots at the cutoff point. Overview plots give a summary of all possible cutoff points with the optimal cutoff marked by a vertical line. The second kinds of plots are Waterfall and Kaplan-Meier plots that are generated for a fixed cutoff point. The overview plots include plots of ORs, HRs and differences in survival. ORs are calculated using the function glm form the R package stats [15] . HRs are calculated using the function coxph from the R package survival [19] . Differences in survival are calculated from the mean survival times in the good prognosis and the poor prognosis group. Mean survival times are estimated from the area under the Kaplan-Meier curve using the maximum time that occurs in the data as uniform time endpoint.
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