Cardiovascular Phenotyping using CMR

Cardiovascular phenotyping using cardiovascular magnetic resonance (CMR) will be performed in all healthy volunteers (3 T Ingenia, Philips or 1.5 T MAGNETOM Aera, Siemens). Conventional balanced steady-state free precession cine images of the vertical and horizontal long-axis planes and the sagittal LV outflow tract view will be acquired. Short-axis cines will be obtained from the mitral valve annulus to the apex (8 mm slices with 2 mm gap). In addition, a single breath hold 3D LV short axis stack will also be acquired in the same orientation. Aortic flow will be assessed using velocity-coded phase contrast imaging. Cardiac volumes, left ventricular mass, atrial sizes and aortic root will be measured in all patients using the CMR 42 software (Circle Cardiovascular Imaging). Normal CMR reference ranges in the Asian population were recently published using standardized protocols in our Image Analysis Laboratory [16 (link)].

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Yap J., Lim W.K., Sahlén A., Chin C.W., Chew K.M., Davila S., Allen J., Goh V., Tan S.Y., Tan P., Lam C.S., Cook S.A, & Yeo K.K. (2019). Harnessing technology and molecular analysis to understand the development of cardiovascular diseases in Asia: a prospective cohort study (SingHEART). BMC Cardiovascular Disorders, 19, 259.

Publication 2019

Ingenia MAGNETOM Aera CMR 42 software

Aortic Aortic root Asian Atrial Axis Cardiac volumes Cardiovascular Healthy volunteers Left ventricular Magnetic resonance Mitral valve Patients Phase contrast

Corresponding Organization :

Other organizations : National Heart Centre Singapore, SingHealth, Duke-NUS Medical School

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Cardiac volumes
Left ventricular mass
Atrial sizes
Aortic root
Aortic flow

control variables

Healthy volunteers
Cardiovascular magnetic resonance (CMR) imaging at 3 T Ingenia (Philips) or 1.5 T MAGNETOM Aera (Siemens)
Conventional balanced steady-state free precession cine images of the vertical and horizontal long-axis planes and the sagittal LV outflow tract view
Short-axis cines from the mitral valve annulus to the apex (8 mm slices with 2 mm gap)
Single breath hold 3D LV short axis stack in the same orientation
Velocity-coded phase contrast imaging for aortic flow assessment
CMR 42 software (Circle Cardiovascular Imaging) for measurements
Normal CMR reference ranges in the Asian population published using standardized protocols

controls

No positive or negative controls explicitly mentioned

Annotations

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