The nine-item Patient Health Questionnaire (PHQ)41 (link) was used to assess depressive symptoms. The Alcohol Use Disorders Identification Test-Consumption Items (AUDIT-C)42 were used to assess alcohol use. The Medical Outcomes Study Short Form 36 (MOS SF-36) Physical Component Summary (PCS)43 score was used to assess physical health and function. Prior trauma, PTSD symptoms, and pre-injury alcohol abuse/dependence were assessed with items from the National Co-morbidity Survey investigations.44 (link) Previously developed items assessing post-injury health service use were administered at the baseline and at the one-, three-, six-, nine-, and twelve-month follow-up interviews.33 (link) Interview items contained self-report descriptions of current medication usage (i.e., name, dosage, duration). We derived from these items the number of anti-depressant prescriptions, attainment of guideline dosages, and adequate adherence to guideline level doses for ≥ 25 or more days. Other medication categories included medications targeting insomnia related to PTSD (i.e., prazosin or trazadone). The number of psychotherapy visits was also assessed at each follow-up time point. Finally, items assessing satisfaction with general health care services and emotional health care services were included in all interviews.33 (link)The investigation determined injury severity at baseline during the index admission from the medical record International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) Codes using the Abbreviated Injury Scale and Injury Severity Score.45 TBI was also prospectively identified in the medical record and categorized by the following ICD-9-CM codes: 800.0–801.9, 803.0–804.9, 850.0–854.1, and 959.01.8 (link), 46 (link) TBI severity was coded based on a previously validated algorithm for hospitalized inpatients.8 (link), 46 (link) Laboratory toxicology results, insurance status, length of hospital and intensive care unit stays, and other clinical characteristics were abstracted from the trauma registry and electronic medical record.