Integrated Multiomics Profiling of KORA Cohort

The KORA F4 study is a population-based cohort of 3,080 subjects living in the southern Germany. Study participants were recruited between 2006 and 2008 comprising individuals with age ranging from 32 to 81. All KORA participants have given written informed consent and the study was approved by the Ethics Committee of the Bavarian Medical Association. For this study, joint data was available for methylation, proteomics, and genotyping measurements of 944 individuals. The DNA methylation data set was determined using the Infinium HumanMethylation450 BeadChip platform which was described in detail previously^{6 (link)}. Aptamer-based proteomics was done using the SOMAscan platform and has been described in detail elsewhere^{2 (link)}. Genotyping was performed using the Affymetrix Axiom array, also described in detail elsewhere^{2 (link)}.

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Zaghlool S.B., Kühnel B., Elhadad M.A., Kader S., Halama A., Thareja G., Engelke R., Sarwath H., Al-Dous E.K., Mohamoud Y.A., Meitinger T., Wilson R., Strauch K., Peters A., Mook-Kanamori D.O., Graumann J., Malek J.A., Gieger C., Waldenberger M, & Suhre K. (2020). Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits. Nature Communications, 11, 15.

Publication 2020

Axiom array

Dna methylation Ethics committee Joint Methylation

Corresponding Organization :

Other organizations : Weill Cornell Medical College in Qatar, Helmholtz Zentrum München, German Centre for Cardiovascular Research, Leiden University Medical Center, Max Planck Institute for Heart and Lung Research

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Variable analysis

independent variables

Age ranging from 32 to 81

dependent variables

DNA methylation data
Proteomics data
Genotyping data

control variables

All KORA participants have given written informed consent
The study was approved by the Ethics Committee of the Bavarian Medical Association

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