Airway hyperresponsiveness (AHR) was assessed by measuring airway resistance (R in cmH2O.s/mL) and lung compliance (C in mL/H2O) in response to intravenous administration of increasing doses of methacholine (Sigma‐Aldrich, MO).19 , 20 Next, AHR was expressed as the effective dose of methacholine required to induce a R of 3 cmH2O.s/mL (ED3).
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Methacholine-Induced Airway Hyperresponsiveness
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Airway hyperresponsiveness
Airway resistance
Intravenous administration
Lung compliance
Methacholine
Corresponding Organization : University of Groningen
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Variable analysis
independent variables
- Increasing doses of methacholine (Sigma‐Aldrich, MO)
- Airway resistance (R in cmH2O.s/mL)
- Lung compliance (C in mL/H2O)
- Effective dose of methacholine required to induce an R of 3 cmH2O.s/mL (ED3)
- Not explicitly mentioned
- No positive or negative controls were explicitly mentioned.
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