Flexible GnRH Antagonist Protocol for Oocyte Retrieval

All participants were treated with a flexible GnRH antagonist protocol. Ovarian stimulation was initiated on cycle day 3, with use of daily injections of 150-300IU of gonadotropin, and when dominant follicles grew to 12-14mm, subcutaneously injecting 0.25mg of GnRH antoganist(Cetrotide, Merck-Serono, Switzerland)was used for suppressing LH surge. And 0.2 mg of GnRH-A was injected subcutaneously at 23: 00 on the trigger day. Oocyte retrieval was performed 33-36h later, cumulus–oocyte complexes were collected, and oocytes were denuded (15 (link)).

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Du Y., Guan Y., Li N., Shi C., Zhang Y., Ren B., Liu J, & Lou H. (2023). Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy?. Frontiers in Endocrinology, 14, 1020055.

Publication 2023

Cetrotide

Cetrotide Follicles Gnrh Gonadotropin Oocyte retrieval Oocytes Ovarian stimulation Trigger

Corresponding Organization : Third Affiliated Hospital of Zhengzhou University

Other organizations : Sun Yat-sen University

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Variable analysis

independent variables

Daily injections of 150-300IU of gonadotropin
Subcutaneous injection of 0.25mg of GnRH antagonist (Cetrotide, Merck-Serono, Switzerland)
Subcutaneous injection of 0.2 mg of GnRH-A at 23:00 on the trigger day

dependent variables

Oocyte retrieval performed 33-36h later
Cumulus–oocyte complexes collected
Oocytes denuded

control variables

Use of a flexible GnRH antagonist protocol
Ovarian stimulation initiated on cycle day 3

controls

No positive or negative controls were explicitly mentioned in the provided information.

Annotations

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