CSF Biomarkers in Alzheimer's Disease

Each subject was categorized according to clinical diagnosis (NC, MCI, AD dementia; Table 1). Established CSF AD biomarkers (Aβ42, total tau [t-Tau], and tau phosphorylated at threonine 181 [p-Tau₁₈₁]) were measured in the middle-aged cohort (n=68) using enzyme-linked immunosorbent assays (Fujirebio, Ghent, Belgium) in the Zetterberg lab, and the same markers were previously measured in the older cohort using Luminex-based multiplex assays (Fujirebio US, Malvern, PA) in Atlanta. We have performed cross-platform validation studies at Emory to show strong linear correlation between these two platforms.^{22 (link)}