Pediatric MRI Acquisition Protocol

The children were imaged on a 3T Siemens Allegra MRI (Erlangen, Germany), without sedation while watching an age-appropriate feature film, using structural T1 imaging followed by 2 DTI acquisitions with opposite phase encoding directions using a twice-refocused spin echo sequence [26 (link)]. The 3D echo planar imaging (EPI) navigated [27 (link)] multiecho MPRAGE [28 (link)] (MEMPR) sequence was acquired in a sagittal orientation with the following parameters: FOV 224 × 224 mm, 144 slices, TR 2530 ms, TE 1.53/3.19/4.86/6.53 ms, TI 1160 ms, flip angle 7°, voxel size 1.3 × 1.0 × 1.0 mm³. DTI was performed in 30 directions with b-value 1000 s/mm², voxel size 2 × 2×2 mm³, TR/TE 9500/86 ms, and 4 volumes with b = 0 s/mm².
MRIs of children with motion corruption, showing incidental brain abnormalities, interslice instabilities or with an interval of over a year from the GMDS were excluded.

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Ackermann C., Andronikou S., Saleh M.G., Kidd M., Cotton M.F., Meintjes E.M, & Laughton B. (2020). Diffusion tensor imaging point to ongoing functional impairment in HIV-infected children at age 5, undetectable using standard neurodevelopmental assessments. AIDS Research and Therapy, 17, 20.

Publication 2020

Allegra MRI

Abnormalities Allegra Brain Children Echo Mris Sedation

Corresponding Organization :

Other organizations : Stellenbosch University, Children's Hospital of Philadelphia, University of Cape Town

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Brain imaging data from structural T1 and DTI acquisitions

control variables

3T Siemens Allegra MRI (Erlangen, Germany)
Children watching an age-appropriate feature film during imaging without sedation
Structural T1 imaging followed by 2 DTI acquisitions with opposite phase encoding directions using a twice-refocused spin echo sequence
3D echo planar imaging (EPI) navigated multiecho MPRAGE (MEMPR) sequence acquired in a sagittal orientation with specific parameters (FOV, slices, TR, TE, TI, flip angle, voxel size)
DTI performed in 30 directions with specific parameters (b-value, voxel size, TR/TE, number of b=0 volumes)

controls

Exclusion of MRIs with motion corruption, brain abnormalities, interslice instabilities, or interval over a year from the GMDS

Annotations

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