Angiotensin II Infusion in Transplant Mice

Five weeks after BMT, the ApoE^−/− recipient mice or the WT recipient mice were implanted with an osmotic pump (ALZET micro-osmotic pump MODEL 1004, DURECT Co., Cupertino, CA, USA)^{22 (link)} and angiotensin II (Ang II) (1900 ng/kg per min) or saline was continuously infused for 4 weeks.^{23 (link),24 (link)}

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Yokokawa T., Misaka T., Kimishima Y., Wada K., Minakawa K., Sugimoto K., Ishida T., Morishita S., Komatsu N., Ikeda K, & Takeishi Y. (2021). Crucial role of hematopoietic JAK2 V617F in the development of aortic aneurysms. Haematologica, 106(7), 1910-1922.

Publication 2021

MODEL 1004

Angiotensin ii Apoe Mice Osmotic Saline

Corresponding Organization :

Other organizations : Fukushima Medical University, Juntendo University

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Variable analysis

independent variables

Type of recipient mice (ApoE^{-/-} or WT)
Infusion of angiotensin II (Ang II) or saline

dependent variables

Not explicitly mentioned

control variables

Time after bone marrow transplantation (BMT) (5 weeks)
Osmotic pump used (ALZET micro-osmotic pump MODEL 1004, DURECT Co., Cupertino, CA, USA)
Infusion rate of Ang II (1900 ng/kg per min)
Duration of infusion (4 weeks)

positive control

WT recipient mice infused with saline

negative control

ApoE^{-/-} recipient mice infused with saline

Annotations

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