Evaluating Liver Fibrosis Using MRE and Ultrasonography

The presence of fatty liver was evaluated using ultrasonography. Severity was graded as normal, mild, moderate, or severe according to the degree of fat infiltration (16 ). Liver echotexture, attenuation, and visualization of the intrahepatic vessel borders and/or the diaphragm were used as the indices. Liver stiffness was measured by MRE. All MRE examinations were performed on MRE hardware (GE Healthcare, Waukesha, Wisconsin, USA) with a 1.5-T imaging system using a two-dimensional MRE protocol (17 (link)). The acquired MRE images were automatically processed. Liver stiffness was assessed by a radiologist using regions of interest, excluding the vessels. The cut-off values for significant and advanced hepatic fibrosis were set at MRE values of ≥ 3.0 kPa (F2) and ≥ 3.6 kPa (F3), respectively (18 (link)). We used various cut-off values for advanced hepatic fibrosis for sensitivity analysis. The range of advanced fibrosis was defined as MRE values of 3.2–4.0 kPa for sensitivity analysis (19 (link)–23 (link)).

Free full text: Click here

Park H., Yoon E.L., Kim M., Lee J., Cho S., Jun D.W, & Nah E.H. (2022). Reappraisal of fibrosis-4 index and non-alcoholic fatty liver disease fibrosis score for advanced fibrosis in average-risk population. Frontiers in Medicine, 9, 1024836.

Publication 2022

MRE hardware

Diaphragm Examinations Fatty liver Fibrosis Hepatic fibrosis Liver Radiologist Sensitivity Ultrasonography Vessels

Corresponding Organization : Korea Health Promotion Institute

Other organizations : Myongji Hospital

Top 5 similar protocols

Variable analysis

independent variables

Ultrasonography used to evaluate the presence and severity of fatty liver, graded as normal, mild, moderate, or severe according to the degree of fat infiltration
Liver stiffness measured by MRE (Magnetic Resonance Elastography)

dependent variables

Degree of fat infiltration in the liver
Liver stiffness values measured by MRE

control variables

All MRE examinations were performed on the same MRE hardware (GE Healthcare, Waukesha, Wisconsin, USA) with a 1.5-T imaging system using a two-dimensional MRE protocol
Liver stiffness was assessed by a radiologist using regions of interest, excluding the vessels
Cut-off values for significant and advanced hepatic fibrosis were set at MRE values of ≥ 3.0 kPa (F2) and ≥ 3.6 kPa (F3), respectively

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!