CTA images were acquired on Siemens CT scanners (Siemens AG, München, Germany) in accordance with a standardized imaging protocol, and the CTA images were reconstructed to 0.60–0.75 mm slices (van der Harst et al., 2019 (link)). Two physicians (Y.S. and M.U.), blinded to the TCD results and clinical information, evaluated the images for scan quality and measured the diameter of the distal and proximal points of each artery from the brain CTA using the TeraRecon AquariusNET iNtuition Viewer [V.4.4.13 (P4)]. The CTA was excluded if the images were determined as uninterpretable due to movement, insufficient contrast in the arteries, or severe artifacts due to clip/coils.
Three points of each ACA, MCA, PCA, and ICA, as well as two points of BA and three communicating arteries were measured for simulation. The details of these locations have previously been described in the study protocol (Shen et al., 2020 (link)) and is sketched inFigure 1 .
In the numerical model, each artery segment is depicted as a uniform thin and homogeneous deformable tube, the diameter of which is the volume-equivalent diameter by multiple measure points from CTA.
Three points of each ACA, MCA, PCA, and ICA, as well as two points of BA and three communicating arteries were measured for simulation. The details of these locations have previously been described in the study protocol (Shen et al., 2020 (link)) and is sketched in
In the numerical model, each artery segment is depicted as a uniform thin and homogeneous deformable tube, the diameter of which is the volume-equivalent diameter by multiple measure points from CTA.
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