At enrolment (T0) and after two months (T2), routinary laboratory measurements (haemoglobin, urea, creatinine, estimated glomerular filtration rate (eGFR) according to the CKD-EPI equation [21 (link)], sodium, potassium, uric acid, calcium, phosphate, parathyroid hormone (PTH), bicarbonates and albumin) were measured on an ADVIA® 1800 Clinical Chemistry Analyzer (Siemens Healthcare Diagnostics, Munich, Germany); total and free serum p-Cresyl Sulphate (t- and f-PCS, respectively) and total and free serum Indoxyl Sulphate (t- and f-IS, respectively) were measured by means of a high-performance liquid chromatography technique coupled with tandem mass spectrometry (B.S.N. Srl, Castelleone, Italy); serum Lp-PLA2 activity was measured with the new PLAC® test (Diazyme Laboratories, Inc., 12889 Gregg Court, Poway, CA, USA).
Nutritional status was assessed by physical examination, measuring body weight, height, BMI (kg/m2), dominant Hand Grip strength (kg) using Hydraulic Hand Dynamometer Owner’s Manual (Sammons Preston, Bolingbrook, IL, USA), according to the reference values [22 ,23 ]. Bioelectrical impedance analysis (BIA) was used to estimate fat-free body mass (kg), fat mass (kg) and phase angle through an Akern model 101 (Akern Srl, Pisa, Italy).
Nutritional status was assessed by physical examination, measuring body weight, height, BMI (kg/m2), dominant Hand Grip strength (kg) using Hydraulic Hand Dynamometer Owner’s Manual (Sammons Preston, Bolingbrook, IL, USA), according to the reference values [22 ,23 ]. Bioelectrical impedance analysis (BIA) was used to estimate fat-free body mass (kg), fat mass (kg) and phase angle through an Akern model 101 (Akern Srl, Pisa, Italy).
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