Genotyping of Non-European Americans

We as part of the EAGLE study accessed all DNA samples and data from non-European Americans within BioVU as of 2011 for genotyping. These data are collectively referred to here as “EAGLE BioVU” [9 (link)]. A total of 15,863 samples were targeted for Illumina Metabochip genotyping. The Illumina Metabochip is a 200,000 variant array designed for replicating genome-wide association study findings (index variants) and for fine mapping select GWAS findings for cardiovascular and metabolic traits and outcomes [13 (link)]. The EAGLE BioVU dataset was generated by the Vanderbilt DNA Resources Core, and genotype calls and quality control were performed by the Population Architecture using Genomic and Epidemiology (PAGE) Coordinating Center as previously described [9 (link), 14 (link)].