After IRB approval, we collected tibial plateau specimens from 78 individuals with osteoarthritis that were undergoing total knee replacement surgery. The specimens were processed for μCT, ELISA and histological examination. We purchased healthy knees specimens from the Nation Disease Research Interchange (NDRI) to serves as controls.
Protocol detail
Osteoarthritis Knee Tissue Analysis
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Elisa
Knees
Osteoarthritis
Surgery
Tibial
Total knee replacement
Corresponding Organization :
Other organizations : Johns Hopkins Medicine, Johns Hopkins University, University of Hong Kong, Sichuan University, Shenzhen Institutes of Advanced Technology
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Variable analysis
independent variables
- Osteoarthritis status (osteoarthritis vs. healthy)
- Tibial plateau structure (measured by μCT)
- Biochemical composition (measured by ELISA)
- Histological characteristics
- Tibial plateau specimens from individuals undergoing total knee replacement surgery (osteoarthritis group)
- Healthy tibial plateau specimens purchased from the National Disease Research Interchange (NDRI) (control group)
- Positive control: Healthy tibial plateau specimens from NDRI
- Negative control: Not explicitly mentioned
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