Comprehensive Evaluation of Chronic Rhinosinusitis with Nasal Polyps

The demographic information (including age and sex) and clinical characteristic (including SIgE test results, serum eosinophil count, eosinophilic granulocytes, visual analog scale [VAS] score, computerized tomography [CT] scoeosinophilre, endoscopic score, the sino‐nasal outcome Test‐20 [SNOT‐22] score) were collected.
The SIgE test results before surgery were collected. The semi‐quantitative detection unit of specific allergen IgE was IU/mL, and the grades were classified into: grade 0, normal, <0.35; grade 1, mild, 0.35–0.7; grade 2, moderate, 0.7–3.5; grade 3, severe, >3.5. Grade 0 was considered negative, and grades 1–3 were considered positive.
The subjective symptoms of rhinosinusitis (nasal obstruction, nasal discharge, and swelling pain in the nasal and facial area) of all the patients before surgery were scored using a VAS score. The range from 0 to 10 represented symptoms gradually aggravating.
The eosinophilic granulocytes in the nasal polyp tissue of the enrolled patients after surgery were counted. If the count was ≥10/HPF, it was defined as ECRS, and if the count was <10/HPF, it was defined as non‐ECRS CRS_wNP.¹⁹The Lund‐Mackay CT score¹⁹ was used to grade the extent of lesions on the coronal CT of the paranasal sinus of the patients before surgery, including the bilateral anterior and posterior sinuses and the ostiomeatal complexes. For the paranasal sinus, 0 represented normal, 1 represented partial shadow, and 2 represented complete shadow. For the ostiomeatal complex, 0 represented no obstruction, and 2 represented obstruction. A maximum of 12 points were scored for each side.
The Lund‐Kennedy score¹⁹ was used to grade the preoperative nasal endoscopy of the patients as endoscopic score, which was divided into three grades: 0 meant that no nasal polyp was found; 1 meant that the size of the nasal polyp did not exceed the middle nasal concha; 2 meant that the lower end of the nasal polyp exceeded the middle nasal concha. Edema: 0 point, no edema; 1 point, slight edema; 2 points, severe edema. Discharge: 0 point, no rhinorrhea; 1 point, clear and thin nose leakage; 2 points, viscous and purulent rhinorrhea.
SNOT‐20²⁰ score was used to score the preoperative questionnaire investigation of the enrolled patients. The Chinese version of SNOT‐22 includes a total of 22 symptoms, involving three aspects: physiological problems, functional limitations and emotional outcomes. The respondents were asked to score 22 symptoms according to their own symptoms of sinusitis. A score of 0 means that they have no problems; 1 point means that the respondent is slightly troubled; 2 points represent moderate distress to the respondents; A score of 3 indicates that the respondents are seriously troubled. The higher the total score of 20 symptoms, the worse the quality of life of the respondents.