Minocycline Dose Optimization for Sleep Deprivation

Minocycline Hydrochloride (Sigma-Aldrich, USA), dissolved in normal saline, was administered to the rats daily by intraperitoneal (i.p.) route, once a day in the morning time, during 48 h of SD. Minocycline at 10, 5, and 2 mg/kg body weight were used to standardize the dose on the behavioral and biochemical scale. The minimum dose of minocycline showing maximum effect was selected, and it was in accordance with some previous studies [28 (link)–30 (link)].

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Wadhwa M., Prabhakar A., Ray K., Roy K., Kumari P., Jha P.K., Kishore K., Kumar S, & Panjwani U. (2017). Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. Journal of Neuroinflammation, 14, 222.

Publication 2017

Minocycline Hydrochloride

Body weight Minocycline Minocycline hydrochloride Normal saline Rats

Corresponding Organization : Defence Institute of Physiology and Allied Sciences

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Variable analysis

independent variables

Minocycline Hydrochloride (Sigma-Aldrich, USA) at doses of 10 mg/kg, 5 mg/kg, and 2 mg/kg body weight

dependent variables

Behavioral and biochemical outcomes

control variables

Minocycline Hydrochloride was dissolved in normal saline
Minocycline was administered to the rats daily by intraperitoneal (i.p.) route, once a day in the morning time, during 48 h of SD

controls

The minimum dose of minocycline showing maximum effect was selected, and it was in accordance with some previous studies [28 (link)–30 (link)].

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