Erastin was synthesized as described (Yagoda et al., 2007 (link)). Additional erastin and Sorafenib analogs were prepared as described in the Supplementary file 1 . Data also available as ‘Extended Materials and Methods’ from Dryad data Repository (Dixon et al., 2014 (link)). The synthesis of (1S, 3R)-RSL3 was described (Yang et al., 2014 (link)). Sorafenib, imatinib, erlotinib, lapatinib, nilotenib, dasatinib, sunitinib, and gefetinib were from SelleckChem (Houston, USA). Unless otherwise indicated, all other compounds were from Sigma-Aldrich (St. Louis, USA).
Free full text: Click here
