University of California, San Diego Health (UCSDH) is a large regional academic health system encompassing 2 acute care hospitals, outpatient primary and specialty medical and surgical care, and emergency patient care. UCSDH is also 1 of 5 academic medical centers within a broader 10-campus University of California system. UCSDH utilizes a commercially available, electronic health record (EHR), Epic (Verona, WI), and hosts over 300 affiliate physicians across 10 medical groups on this EHR. San Diego County served as a quarantine site for both Chinese expatriates and cruise ship passengers, and also experienced community spread of COVID earlier than much of the US.19 An Incident Command Center (ICC) was established at UCSDH on February 5, 2020 for 24-hour monitoring and adaptation to rapidly evolving conditions and recommendations on a local, state, federal, and global scale. An assessment of the institutional current state revealed the need to develop a rapid screening process, hospital-based and ambulatory testing, new orders with clinical decision support, reporting/analytics tools, and the enhancement/expansion of current patient-facing technology.