Estrogen Modulation of Global Cerebral Ischemia
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Corresponding Organization :
Other organizations : Augusta University, The University of Texas Health Science Center at San Antonio, Center for Neuroscience and Regenerative Medicine
Protocol cited in 5 other protocols
Variable analysis
- Timing of 17β-estradiol (E2) Alzet minipump implantation: Immediate (
Imm ) or 10 weeks after ovariectomy (10W ) - Treatment: Placebo or 17β-estradiol (E2)
- Not explicitly mentioned
- Sprague Dawley female rats (3-month old)
- Bilateral ovariectomy
- Subcutaneous implantation of Alzet minipumps in the upper mid-back region under the skin
- Global cerebral ischemia (GCI) performed one week after Alzet minipump implantation
- Rectal temperature maintained at 36.5 to 37.5°C throughout the experiment with a thermal blanket
- Positive control: Sham group underwent identical procedures except that the common carotid arteries were simply exposed, but not occluded.
- Negative control: Not explicitly mentioned
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