Genetic Analysis of Alzheimer's Disease in Spanish Population
The GR@ACE-DEGESCO cohort comprises AD patients and controls from the Spanish population. Patients with AD were collected from the ACE Alzheimer Center Barcelona and 12 other cohorts included in the Dementia Genetics Spanish Consortium (DEGESCO) (Table S11). Control individuals were provided by the ACE Alzheimer Center (Barcelona, Spain), Valme University Hospital, the Spanish National DNA Bank Carlos III (Salamanca, Spain), and other DEGESCO members. DNA extracted from peripheral blood or saliva (Table S11) was genotyped in the Spanish National Center for Genotyping (CeGen, Santiago de Compostela, Spain) using the Axiom 815K Spanish Biobank Array (Thermo Fisher), as described previously [26 (link),27 (link)].
García-González P., de Rojas I., Moreno-Grau S., Montrreal L., Puerta R., Alarcón-Martín E., Quintela I., Orellana A., Andrade V., Adami P.V., Heilmann-Heimbach S., Gomez-Garre P., Periñán M.T., Alvarez I., Diez-Fairen M., Nuñez Llaves R., Olivé Roig C., Garcia-Ribas G., Menéndez-González M., Martínez C., Aguilar M., Buongiorno M., Franco-Macías E., Saez M.E., Cano A., Bullido M.J., Real L.M., Rodríguez-Rodríguez E., Royo J.L., Álvarez V., Pastor P., Piñol-Ripoll G., Mir P., Lara M.C., Padilla M.M., Sánchez-Juan P., Carracedo A., Valero S., Hernandez I., Tàrraga L., Ramirez A., Boada M, & Ruiz A. (2023). Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men. International Journal of Molecular Sciences, 24(2), 898.
Other organizations :
Fundación Pública Galega de Medicina Xenómica, Universidade de Santiago de Compostela, University of Cologne, University of Bonn, University Hospital Bonn, Universidad de Sevilla, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, University Hospital Mútua de Terrassa, Mútua Terrassa, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Central University Hospital of Asturias, Hospital Universitario De Cabueñes, Centro Andaluz de Biología del Desarrollo, Centro de Biología Molecular Severo Ochoa, Autonomous University of Madrid, Hospital La Paz Institute for Health Research, Hospital Universitario de Valme, Universidad de Málaga, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla, Universidad de Cantabria, Hospital Universitari de Santa Maria, Biomedical Research Institute of Lleida, Fundacion Centro De Investigacion De Enfermedades Neurologicas, German Center for Neurodegenerative Diseases, Institute for Neurodegenerative Disorders, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Genotyped using the Axiom 815K Spanish Biobank Array (Thermo Fisher)
controls
Positive control: AD patients from the ACE Alzheimer Center Barcelona and 12 other cohorts included in the Dementia Genetics Spanish Consortium (DEGESCO)
Negative control: Control individuals provided by the ACE Alzheimer Center (Barcelona, Spain), Valme University Hospital, the Spanish National DNA Bank Carlos III (Salamanca, Spain), and other DEGESCO members
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