C57/BL6 and Grn−/− mice [38 (link)] were obtained from The Jackson Laboratory. Ctsd−/− [39 (link)], Ctsb−/− [40 (link)], Ctsl−/− [41 (link)], Ctsb−/− Ctsl−/− [33 (link)], Ctsk−/− [42 (link)] and Ctsz−/− [43 (link)] mice were characterized previously. PSAP knockout mice were previously described [44 (link)]. All animals (1–6 adult mice per cage) were housed in a 12 h light/dark cycle.
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