Controlled Fluoxetine Delivery in Primates

The animals were divided into 2 groups. One group was treated with FLX pellets (Innovative Research of America, Sarasota, FL) for 4 weeks at a dose of 3 mg/kg/day, whereas the other group was treated with control pellets (Innovative Research of America) for the same period. This dosage was chosen based on results of a previous study showing behavioral alterations in marmosets receiving the same dose [14 (link)]. Animals were anesthetized with an intramuscular injection of ketamine hydrochloride (50–60 mg/kg) and medetomidine hydrochloride (0.1–0.15 mg/kg), followed by atipamezole hydrochloride injection of 0.5–0.75 mg/kg. FLX or control pellets were implanted subcutaneously on their backs [15 (link)].

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Ohira K., Hagihara H., Miwa M., Nakamura K, & Miyakawa T. (2019). Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset. Molecular Brain, 12, 69.

Publication 2019

control pellets

Animals Atipamezole Intramuscular injection Ketamine hydrochloride Marmosets Medetomidine hydrochloride Pellets

Corresponding Organization :

Other organizations : Fujita Health University, Kyoto University

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Variable analysis

independent variables

Treatment with FLX pellets for 4 weeks at a dose of 3 mg/kg/day
Treatment with control pellets for 4 weeks

dependent variables

Not explicitly mentioned

control variables

Dosage of 3 mg/kg/day based on a previous study
Anesthesia with ketamine hydrochloride (50–60 mg/kg) and medetomidine hydrochloride (0.1–0.15 mg/kg), followed by atipamezole hydrochloride injection of 0.5–0.75 mg/kg
Subcutaneous implantation of FLX or control pellets on the animals' backs

controls

Positive control: Animals treated with FLX pellets
Negative control: Animals treated with control pellets

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