HBMEC monolayer integrity was ensured during BBB transport assays by TEER measurements and sodium-fluorescein paracellular permeability assessment, as previously described [37 (link)]. TEER readings were performed using an EndOhmTM chamber coupled to an EVOMX resistance meter (World Precision Instruments, Inc., Sarasota, FL, USA) and sodium fluorescein levels were measured using a Hitachi F-2000 fluorescence spectrophotometer.
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