Transmission electron microscopy was performed as described previously [34 (link)]. The investigator was blinded to group allocation. A whole-mount bright field was obtained using a Nikon SMZ1000 Stereomicroscope. Light and fluorescent microscopic images were obtained by a Nikon Eclipse 90i microscope system, a Nikon confocal microscope system A1+ (Nikon Instruments, Melville, NY, USA), and a ZEISS LSM 980 with Airyscan 2 confocal microscope (Carl Zeiss Microscopy, LLC, White Plains, NY, USA).
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