Hyperglycemic Zebrafish Model for E70 PRA Extract

After the determination of MTC, the hyperglycemic zebrafish model was established as described in section “2.8.1. Determination of maximum detection concentration.” The zebrafish without any treatment was taken as normal group. The zebrafish treated with 500, 1,000, and 2,000 μg/ml of E70 PRA extract were taken as treatment groups, while the zebrafish treated with 18 μg/ml pioglitazone (PGTZ) was used as positive control. The blood glucose level (G) was determined with blood glucose meter, the hypoglycemic effect was calculated as follows:

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Zhang L., Deng M., Wang S.Y., Ding Q., Liu J.H., Xie X., Huang Y.H, & Tu Z.C. (2023). Mitigation of Paeoniae Radix Alba extracts on H2O2-induced oxidative damage in HepG2 cells and hyperglycemia in zebrafish, and identification of phytochemical constituents. Frontiers in Nutrition, 10, 1135759.

Publication 2023

Blood glucose Hypoglycemic effect Pioglitazone Zebrafish

Corresponding Organization : Jiangxi Normal University

Other organizations : State Key Laboratory of Food Science and Technology, Nanchang University

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Variable analysis

independent variables

E70 PRA extract at 500, 1,000, and 2,000 μg/ml

dependent variables

Blood glucose level (G)

control variables

Zebrafish without any treatment (normal group)
Zebrafish treated with 18 μg/ml pioglitazone (PGTZ) (positive control)

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