The gene expression profiles of the GSE167033 dataset which included 46 liver tissues of mice that had been treated with CCl4 at different time points (2 and 8 h, 1, 2, 4, 6, 8, and 16 days following CCL4 administration) were collected from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/ ). The details of the GSE167033 dataset are listed in Additional file 2 : Table S1.
The samples were divided into the case group (with 16 days CCl4 treatment) and the control group (without CCl4 treatment). Our previous study found that 2 weeks after CCl4 was intraperitoneally injected into mice, fibrosis related changes occurred in hepatocytes, liver tissues and gene expression [14 (link)]. Therefore, we chose the sample with the longest 16 days of administration in the dataset as the liver fibrosis case group.
The samples were divided into the case group (with 16 days CCl4 treatment) and the control group (without CCl4 treatment). Our previous study found that 2 weeks after CCl4 was intraperitoneally injected into mice, fibrosis related changes occurred in hepatocytes, liver tissues and gene expression [14 (link)]. Therefore, we chose the sample with the longest 16 days of administration in the dataset as the liver fibrosis case group.
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